Cancer Stem Cells - Philosophy and Therapies.pdf

Cancer Stem Cells - Philosophy and Therapies

Lucie Laplane

AN INNOVATIVE THEORY proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy. Rather than treat cancer by aggressively trying to eliminate all cancerous cells—with harmful side effects for patients—CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells—the abilities to self-renew and to differentiate. According to this theory, only CSCs and no other cancer cells can induce tumor formation. To date, researchers have not agreed on the defining feature of CSCs—their stemness. Drawing from a philosophical perspective, Laplane shows that there are four possible ways to understand this property : sternness can be categorical (an intrinsic property of stem cells), dis-positional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cells relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers.

Cancer - Targeted therapies | Britannica Cancer - Cancer - Targeted therapies: Knowing in detail the specific molecules that are involved in tumour growth and progression makes it possible to design new drugs or to screen for existing compounds that will interfere with the molecules’ function, thus blocking the growth and spread of cancer. Those molecules are described as “targets,” and the drugs that neutralize them are known

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9780674088740 ISBN
Cancer Stem Cells - Philosophy and Therapies.pdf


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Notes actuelles

Sofya Voigtuh

Cancer Stem Cells - Stemcells Identifying the stem cell-like cells within cancers and understanding their properties will be crucial if effective anti-cancer therapies are to be developed, since different populations of cancer cells within a tumour can switch back and forth between one cells that divide rapidly but do not invade, and stem cell-like cells that divide slowly but are highly metastatic.

Mattio Müllers

01/12/2009 · A cancer stem cell is defined as an undifferentiated cell with the ability to self-renew, differentiate to multiple lineages and initiate tumors that mimic the parent tumor. In this review, we focus on glioblastomas, describing recent progress and problems in characterizing these cells. There have been advances in cancer stem cell culture, but tumor cell heterogeneity has made purification of Cancer stem cells (CSCs), cervical CSCs and …

Noels Schulzen

Cancer Stem Cells: Philosophy and Therapies | Lucie Laplane | ISBN: 9780674088740 | Kostenloser Versand für alle Bücher mit Versand und Verkauf duch Amazon.

Jason Leghmann

The recent book by LaPlane on Cancer Stem Cells is a brilliantly well-crafted introduction to the field from is a philosophical perspective. Such an approach is significant since it was Galen who promoted the use of logic, and in fact the full trivium, as an integral part of the practice of medicine. Words do mean something and the term "cancer stem cell", the CSC, has been used by many over the last decade and …

Jessica Kolhmann

Several philosophers have weighed in on this ... The cancer stem cell theory in part is descended from the view ... new avenues for both treatment and prevention.